Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- correlation between adropin and testosterone
研究概览
简要总结
Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia.
correlation between adropin and testosterone will be evaluated.
详细描述
Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia.
Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia.
Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age from 18 years to 50 years. Clinically free except from obesity
排除标准
- •Diabetes mellitus Hypertension Heart failure Kidney disease Smoking
结局指标
主要结局
correlation between adropin and testosterone
时间窗: 6 months
changes in total testosterone levels
时间窗: 6 months
expected lower testosterone levels in obese men compared to normal men
changes in lipid profile (TC, TG, LDL, HDL) levels
时间窗: 6 months
expected higher TC, TG, LDl levels and lower HDL levels in obese men compared to normal
changes in adropin level
时间窗: 6 months
expected lower adropin levels in obese men compared to normal men
changed in adiponectin levels
时间窗: 6 months
expected lower adiponectin level in obese men compared to normal men
correlation between adropin and adiponectin
时间窗: 6 months
次要结局
未报告次要终点
研究者
Asmaa Abdel-mageed Muhammed
Assistant lecturer
Aswan University Hospital