NCT05495685Unknown不适用
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- The sensitivity and specificity of multi-cancer early detection by the combined model in cancer arm and benign disease arm
研究概览
简要总结
DAYBREAK is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, serum protein markers, blood miRNA markers and others, in which of 450 participants will be enrolled. The development and validation of the model will be conducted in participants with early stage cancers and benign disease through a two-stage approach. The sensitivity and specificity of the model in pancreatic cancer early detection will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
The sensitivity and specificity of multi-cancer early detection by the combined model in cancer arm and benign disease arm
时间窗: 12 months
次要结局
- The difference of sensitivity and specificity in pancreatic cancer participants at different clinical stages.(12 months)
- Sensitivity and specificity for detecting pancreatic cancer of a cfDNA methylation-based model, in combination with other biomarkers.(12 months)
- Sensitivity and specificity for detecting pancreatic cancer of a the protein panel-based model, in combination with other biomarkers.(12 months)
- Sensitivity and specificity of the blood miRNA-based model in detecting pancreatic cancer.(12 months)
研究者
Guo ShiWei
Associated Professor at the Institute of Pancreatic Surgery
Changhai Hospital
研究点 (1)
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