JPRN-jRCTs051200115已完成未知
ovel gastrointestinal-mediated mechanism of action of metformin
Sakaguchi Kazuhiko0 个研究点目标入组 5 人开始时间: 2021年1月19日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 5
研究概览
简要总结
A PET/MRI imaging protocol (PET/MRE) was developed to allow quantification of radioactivity in a fixed volume of the intestinal tract. The glucose excretion into the intestinal lumen in metformin users was approximately 1.6 g/hour, comparable to the urinary glucose excretion in SGLT2 inhibitor users.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1.Patients with type 2 diabetes
- •2.Patients taking more than 1000 mg of metformin hydrochloride per day
- •3.Patients with no obvious lesions in the lower gastrointestinal tract
- •4.Patients who were 20 years of age or older and Under 75 years old at the time of obtaining consent
- •5.Patients who have given their voluntary written consent to participate in this clinical study
排除标准
- •1.Patients with contraindications to scopolamine butylbromide
- •2.Patients suffering from dementia or mental illness
- •3.Patients with possible bowel perforation or obstruction
- •4.Patients with metals in the body that are not amenable to PET/MRE testing
- •5.Pregnant or breast feeding patients
- •6.Other patients who are deemed inappropriate by the investigators of this clinical study
研究者
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