Delirium, Electroencephalographic Alterations and Cortical Spreading Depression in Critical Illness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- The occurence of electroencephalographic alterations and potential electroencephalographic signatures prior to and during delirium in the ICU
研究概览
简要总结
Delirium in the intensive care unit is an acutely developed brain dysfunction affecting up to 80 % of patients. It is associated with significantly increased morbidity and mortality during admission and post-discharge. The mechanism behind the condition is poorly understood but assumably multifactorial, and the purpose of this study is to investigate the pathophysiology further.
详细描述
The pathophysiology behind delirium in critical illness is not clarified but assumed to involve inflammation, changes in cerebral perfusion and neurotransmission, sleep deprivation and the use of i.e. sedatives.
Cortical spreading depression is a phenomenon occuring in critically ill patients with acute cerebral trauma and likely associated with significant secondary neuron damage.
The hypothesis is that
- Delirium in critically ill patients without acute cerebral damage is a clinical manifestation of cortical spreading depression and can be recorded in a noninvasive direct current-electroencephalography
- Electroencephalographic alterations or potentially specific signatures occur in delirium and thus, delirium can be predicted by recording continuous alternate current electroencephalography on admission in an ICU
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •expected admission in the ICU >24 hours
排除标准
- •Cerebral trauma <6 months
- •existing delirium
- •severe dementia
结局指标
主要结局
The occurence of electroencephalographic alterations and potential electroencephalographic signatures prior to and during delirium in the ICU
时间窗: 7 days
次要结局
- The occurence of cortical spreading depression in noninvasive direct current-EEG in critically ill patients without acute cerebral trauma(Cortical spreading depression in the ICU)
研究者
Rikke Malte Nielsen, M.D.
M.D.
Glostrup University Hospital, Copenhagen