NCT07653464尚未招募1 期
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 64
- 试验地点
- 1
研究概览
简要总结
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 65 years of age
- •Individuals with obesity and comorbid IR
- •BMI 30-45 kg/m2
- •Waist circumference ≥102 cm (men) or ≥88 cm (women)
- •HOMA-IR ≥2.5
- •Healthy normal weight adults
- •BMI 18-25 kg/m2
- •Waist circumference <94 cm (men) and <80 cm (women)
- •HOMA-IR <2
排除标准
- •Pregnancy, breastfeeding
- •Unable to provide consent
- •Diabetes or polycystic ovarian syndrome
- •Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
- •Nerve/neurologic disease
- •Uncontrolled hypertension (systolic blood pressure >180 mmHg and/or diastolic blood pressure >100 mmHg)
- •Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
- •Current smoking, tobacco, nicotine use
- •Use of pharmacological therapy for weight loss
- •Body weight change >10% within the last 6 months
- •Adherence to >150 min/week of moderate-to-vigorous physical activity/exercise
- •Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
- •Claustrophobia
- •Non-MRI compatible metal implants
研究组 & 干预措施
Insulin (Doppler)
Experimental
Human insulin (160 IU) will be administered using an intra-nasal device
干预措施: human insulin (Drug)
Insulin (MRI)
Experimental
Human insulin (160 IU) will be administered using an intra-nasal device.
干预措施: human insulin (Drug)
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia
研究点 (1)
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