Monitoring of MDRO Dynamics and Resistance Mechanisms in a University Hospital Network
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14,607
- 试验地点
- 2
- 主要终点
- monitoring of MDRO prevalence
研究概览
简要总结
Survey on the prevalence of MDRO to monitor the import of MDRO from the community. Rectal swabs will be taken and cultivated. Survey on community-onset and nosocomial bloodstream infections will be documented and strains will be isolated. For each BSI a clinical data set will be obtained (e.g. patient age, gender, date of hospitalization, antibiotic therapy). Genetic analysis of MDRO from the prevalence and BSI study. In a subset of patients the microbiome-resistome interactome will be analysed in more detail. Furthermore, the impact of infection control measures due to the Covid-19 pandemic on nosocomial BSI will be investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 18 years old
- •informed consent
- •inpatient
排除标准
- •less than 18 years old
- •Not capable of giving informed consent
- •outpatient
结局指标
主要结局
monitoring of MDRO prevalence
时间窗: at hospital admission
obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
integrate novel techniques for microbiome-resistome interaction analysis
时间窗: through study completion, after 4 years
obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
monitoring of blood stream infections
时间窗: during hospitalization, up to 4 weeks
obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure
次要结局
未报告次要终点
研究者
Nadja Käding
Dr. med.
University of Luebeck