NCT00833157Unknown1 期
Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 入组人数
- 36
- 主要终点
- cartilage biomarkers
研究概览
简要总结
The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.
The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 50 to 70 years
- •Bilateral tibiofemoral osteoarthritis of the knee on x-ray
- •American College of Rheumatology (ACR) clinical classification criteria
排除标准
- •Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases
- •Excess alcohol use (> 21 alcoholic drinks per week)
- •Severe overweight (BMI > 35)
- •History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion
研究组 & 干预措施
Glucosamine
Experimental
干预措施: glucosamine sulphate (Drug)
Ibuprofen
Experimental
干预措施: ibuprofen (Drug)
Placebo
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
cartilage biomarkers
时间窗: We measure before and after 12 weeks strength training
muscle strength and hypertrophy
时间窗: We measure before and after 12-weeks strength training.
次要结局
- muscle regeneration and function(We measure before and after 12-weeks strength training.)
研究者
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