Pilot Study Pancreatic and Ovarian Screening MR Imaging of Rapid With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- define optimized acquisition
研究概览
简要总结
The purpose of this study is to create a rapid scan of the pancreas and ovaries that could be used in the future to screen patients at risk for pancreatic or ovarian cancers. Currently, Magnetic Resonance Imaging (MRI) examinations of the pancreas and ovaries can last 30-45 minutes each. The investigators hope to create a rapid pancreatic and ovarian MRI evaluation that can be used as a screening tool that is completed in approximately 15 minutes. They will compare different tools available on modern MRI scanners to see which one reliably offers high quality images of the pancreas and ovaries.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •A minimum of 5 and maximum of 60 evaluable patients will be imaged on this study. Description of the subject inclusion and
排除标准
- •are listed below.
- •Inclusion Criteria:
- •BRCA 1 or 2 mutation
- •Patients scheduled to undergo screening breast MRI with contrast
- •Exclusion Criteria:
- •Patients with known breast cancer
- •Patients unable to complete their scheduled breast MRI
- •Patients with prior pancreatic surgery or cancers
- •Patients with prior ovarian cancer or surgery involving removal of one or both ovaries
- •Patients with prior abdominal or pelvic surgery
结局指标
主要结局
define optimized acquisition
时间窗: 1 year
The images will be evaluated qualitatively for image quality from 1 to 5 with 5 = not adequate and 1 = adequate image quality by two radiologists in consensus. If both radiologists give a score of 1, the sequence will be considered to be adequate in image quality. Quantitative measurements of SNR will be performed on the pancreatic head, body and tail, and ovarian tissue by region of interest (ROI) analysis. Final acquisition times and spatial resolution for each sequence will be recorded.
次要结局
未报告次要终点