Combined Dexmedetomidine and Glycopyrrolate Therapy for Prevention of Catheter Related Bladder Discomfort After Transurethral Bladder Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- The incidence of catheter-related bladder discomfort
研究概览
简要总结
Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation. The mechanism of the catheter-related bladder discomfort is similar to that of overactive bladder, in which muscarinic acetylcholine receptors are stimulated. The catheter-related bladder discomfort is a well known predisposing factor for emergence delirium after general anesthesia. In this study, we aimed to compare the incidence of catheter-related bladder discomfort between dexmedetomidine only therapy and combind dexmedetomidine and glycopyrrolate therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I and II
- •elective transurethral resection of bladder tumor under general anesthesia
排除标准
- •arrhythmia
- •bladder outflow obstruction
- •overacitve bladder
- •end stage renal disease
- •neurogenic bladder
- •morbid obesity
- •psychiatric disorder
研究组 & 干预措施
Dexmedetomidine only
dexmedetomidine is administered during the surgery
干预措施: Dexmedetomidine (Drug)
Combined dexmedetomidine and glycopyrrolate
glycopyrrolate and dexmedetomidine are administered during the surgery
干预措施: Glycopyrrolate + dexmedetomidine (Drug)
结局指标
主要结局
The incidence of catheter-related bladder discomfort
时间窗: 0 minute after entering the post-anesthetic care unit
No = not complaining of bladder discomfort on asking; Mild = report discomfot only on questioning; Moderate: report without questioning without behavior responses; Severe = report without questioniing accompanied by behavior responses. Mild, Moderate, Severe bladder discomfort is defined to have catheter-related bladder discomfort
次要结局
- Sedation score(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
- Dry mouth(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
- postoperative nausea and vomiting(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
- Emergence agitation(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
- Delirium(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
- Postoperative pain(0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit)
研究者
Eunah Cho, MD
Assistant professor
Kangbuk Samsung Hospital