Clinical and Radiographic Evaluation of Hyaluronan-Nano Hydroxyapatite Composite Graft in the Regeneration of Infrabony Defects in Chronic Periodontitis Patients
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- efficacy of Hyaluronan-Nano hydroxyapatite composite graft in comparison with Nano hydroxyapatite graft alone, in the treatment of infrabony defects.
研究概览
简要总结
Periodontitis is an inflammatorydisease of the supporting tissues of the teeth caused by specificmicroorganisms or groups of specific microorganisms, resulting in progressivedestruction of the periodontal ligament and alveolar bone with pocket formation,recession or both. 1
Periodontal therapy aims primarily atthe arrest of progression of disease, along with formation of new bone,cementum and periodontal ligament (PDL). 2
Various types of bone grafts have beenused along with conventional surgical procedures for regeneration of bone andPDL.3 Hydroxyapatite, having a biomimetic property of replicatingthe native mineral content of bone tissue, is most commonly used. It is osteophilicand osteoconductive. Osteoconductive materials neither inhibit nor induce boneformation. They only act as a scaffold for bone formation.4
Hyaluronan or Hyaluronic acid, animportant component of extra cellular matrix, on the other hand, has astimulatory effect on osteoblasts. Thusit imparts osteogenic and osteoconductive properties to bone graft, when addedto it. It also acts as a connective tissuescaffold allowing cell growth and regeneration of bone.5
Hence an attempt is being made in thisstudy to combine the properties of both the above materials for regeneration ofbone.
As per our knowledge there are verysparse studies evaluating the efficacy of hyaluronan and bone graft together.Thus, in this study, an attempt is made to evaluate the regenerative propertyof hyaluronan in combination with Nano-hydroxyapatite bone graft in comparisonwith Nano-hydroxyapatite bone graft alone, in the surgical management ofinfrabony defects, in patients with chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •Systemically healthy male and female patients in the age range of 30-55 years having chronic generalised periodontitis.
- •Patients with contralateral intrabony pockets measuring more than or equal to 6mm.
- •Patients with radiographic evidence of bilateral vertical/angular defects.
- •Consenting patients who are cooperative and ready for regular follow up.
排除标准
- •Patients on antibiotic therapy in the previous six months.
- •Patients who have undergone any periodontal therapy in past 6 months.
- •Pregnant /lactating women.
- •Patients who are medically compromised or under therapeutic regimen that may alter the probability of soft tissue and bone healing.
结局指标
主要结局
efficacy of Hyaluronan-Nano hydroxyapatite composite graft in comparison with Nano hydroxyapatite graft alone, in the treatment of infrabony defects.
时间窗: 12 month period (3,6,9,12 month)
次要结局
- to evaluate Clinical Parameters and Bone fill(3,6,9,12 months)