Multimodal Cardiovascular and Hepatic Population Imaging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,400
- 试验地点
- 1
- 主要终点
- Establishement of reference nomograms accounting for sex in diaphragm
研究概览
简要总结
Medical imaging is increasingly important for understanding diseases, detecting them early, and personalizing treatments. New imaging techniques, which can measure processes in the body without surgery, are opening the door to a more precise approach to medicine. Instead of relying on general probabilities, this technology allows us to analyze specific factors in a person's health, leading to better predictions and targeted treatments. One key challenge in medicine today is reducing "residual individual risk"-the remaining health risks that current treatments don't fully address. This involves understanding how factors like age, sex, genetics, and environment affect our health, particularly when it comes to conditions like heart and liver disease. By using imaging to distinguish between normal aging and disease, we can better assess individual health risks.
The current project will create a large collection of medical images linked with health data from a broad population across France. Using advanced, non-invasive techniques such as MRI and ultrasound, researchers will analyze the heart, blood vessels, and liver in detail, considering factors like gender and health risk profiles. This will help improve our understanding of these diseases, which are often silent and not well understood, providing direct benefits to the participants. Ultimately, the goal is to optimize imaging technologies for large-scale studies, which will help enhance early detection and prevention for everyone.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participation to the Constances cohort
- •Age ≥ 20 years
- •No overt cardiovascular or hepatic disease or related symptoms
- •No known family or personal genetic disease
- •Affiliation with a social security scheme or beneficiary of such a scheme.
- •Agreement to sign the consent
排除标准
- •Renal function impairment with GFR < 60 mL/min/1.73m2
- •Deprived of liberty or persons subject to a legal protection measure (under guardianship or trusteeship)
- •People with contraindications to MRI (claustrophobia, presence of metallic elements…)
- •Pregnant or breastfeeding woman (pregnancy urinary test before inclusion for women of childbearing age).
研究组 & 干预措施
Constances volunteers
The 2400 volunteers will be stratifed according to age in decades from 20 to 80 years of age and matched 1:1 male:female.
干预措施: Imaging examinations (Radiation)
Constances volunteers
The 2400 volunteers will be stratifed according to age in decades from 20 to 80 years of age and matched 1:1 male:female.
干预措施: Paramedical examinations (Other)
Constances volunteers
The 2400 volunteers will be stratifed according to age in decades from 20 to 80 years of age and matched 1:1 male:female.
干预措施: Medical examination (Other)
Constances volunteers
The 2400 volunteers will be stratifed according to age in decades from 20 to 80 years of age and matched 1:1 male:female.
干预措施: Echocardiography (Other)
结局指标
主要结局
Establishement of reference nomograms accounting for sex in diaphragm
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of diaphragm
Establishement of reference nomograms accounting for age in diaphragm
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of diaphragm
Establishement of reference nomograms accounting for sex in kidney
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of kidney
Establishement of reference nomograms accounting for age in heart
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of qualitative and quantitative morphology, function, quantitative tissue characterization of the heart
Establishement of reference nomograms accounting for sex in heart
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of qualitative and quantitative morphology, function, quantitative tissue characterization of the heart
Establishement of reference nomograms accounting for age in liver
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of quantitative steatosis, fibrosis
Establishement of reference nomograms accounting for sex in liver
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of quantitative steatosis, fibrosis
Establishement of reference nomograms accounting for age in adipose tissue
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of volumes of subcutaneous, visceral and epicardial adipose tissues
Establishement of reference nomograms accounting for sex in adipose tissue
时间窗: During 36 months of analysis (after 60 months of inclusion)
Ultrasound and MRI images analysis of volumes of subcutaneous, visceral and epicardial adipose tissues
次要结局
- Advanced Imaging profiling of Heart(During 36 months of analysis (after 60 months of inclusion))
- Advanced imaging profiling in Liver(During 36 months of analysis (after 60 months of inclusion))
- Advanced biological phenotyping(During 36 months of analysis (after 60 months of inclusion))
- identification of genetic risk markers for cardio-metabolic diseases(During 36 months of analysis (after 60 months of inclusion))