Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- morphological of tubal cilia
研究概览
简要总结
Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women
详细描述
Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP.
Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with scheduled salpingectomy (Ectopic pregnancy, hysterectomy for prolapsus, adenomyosis or myomectomy)
- •Major patients ( >18 years)
排除标准
- •Patient not willing to participate in the study
研究组 & 干预措施
Salpingectomy for Extra-Uterine Pregnancy
patients with salpingectomy for Ectopic Pregnancy
干预措施: salpingectomy (Procedure)
hysterectomies
patients with hysterectomy for prolapsus, adenomyosis or myomectomy
干预措施: hysterectomy (Procedure)
结局指标
主要结局
morphological of tubal cilia
时间窗: through study completion, an average of 6 week after surgery
Molecular compositor of tubal ciliar by immunofluorescence study of 14 proteins in vivo and in vitro (tissue cells from patient fallopian tubes)
Molecular difference in tubal cilia between patients with or without GEU salpingectomy
时间窗: through study completion, an average of 6 week after surgery
compares molecular compositor of tubal ciliar by immunofluorecence study of 14 proteins in vivo and in vitro between patients with or without GEU salpingectomy
molecular tubal cilia
时间窗: through study completion, an average of 6 week after surgery
Ultrastructure morphology of tubal cell cilia by electron microscopy
functional composition of tubal cell by video microscopy
时间窗: through study completion, an average of 6 week after surgery
amplitude of moment by video microscopy
次要结局
未报告次要终点