A Registered Cohort Study on Spastic Paraplegia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Spastic Paraplegia Rating Scale (SPRS)
研究概览
简要总结
The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with the clinical diagnosis of spastic paraplegia
- •Clinical diagnosis of patients with spastic paraplegia
- •Unrelated healthy controls
排除标准
- •Decline to participate.
- •There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.
结局指标
主要结局
Spastic Paraplegia Rating Scale (SPRS)
时间窗: 6 months
Disease severity will be assessed by application of the Spastic Paraplegia Rating Scale (SPRS), a clinical rating scale measuring disease severity in Hereditary Spastic Paraplegia (Schule et al. Neurology 2006). The SPRS contains 13 items, each ranging from 0 to 4 points. The total score is calculated as the sum of all items, yielding a range for the total score between 0 and 52. Hereby, higher SPRS total scores indicate more severe disease.
次要结局
未报告次要终点
研究者
Wan-Jin Chen
The Vice-Director for the Department of Neurology
First Affiliated Hospital of Fujian Medical University