NCT02077231已完成不适用
Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients
Xiaodong Zhou0 个研究点目标入组 30 人开始时间: 2011年9月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- change of the density of conjunctival goblet cells
研究概览
简要总结
Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year.
排除标准
- •any systemic diseases which may cause ocular damage;
- •previous ocular trauma or surgery;
- •contact lens wear history in previous 6 months;
- •application of any artificial tears 3 months ago;
- •allergic to any of the drugs we used during examination.
研究组 & 干预措施
vitamin A palmitate eye gel
Experimental
0.1% vitamin A palmitate; Sinqi, Shenyang, China
干预措施: Vitamin A (Drug)
carbomer eye gel
Experimental
0.2% Carbomer 940; Bausch & Lomb, Aschheim, Germany
干预措施: carbomer eye gel (Drug)
结局指标
主要结局
change of the density of conjunctival goblet cells
时间窗: change from Baseline in goblet cell density at 6 months
次要结局
- tear film parameters changes in patients(change from baseline in TBUT and Schirmer test at 6 months)
- changes of ocular irritation in patients(change from baseline in OSDI scores at 6 months)
研究者
Xiaodong Zhou
Professor of Ophthalmology
Shanghai Jinshan Hospital
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