Pregnancy and Implantation Rates When Embryos Are Selected Based on a Single Day 3 Score (Day 3)vs Graduated Embryo Score(GES) Plus Soluble Human Leukocyte Antigen-G Expression.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 214
- 主要终点
- Pregnancy and implantation rates
研究概览
简要总结
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
详细描述
Comparing pregnancy rates and implantation rates when embryos are selected using the most common criteria for embryo selection on day 3 - the morphology-(number of blastomere, their shape and size and the percentage of fragmentation)vs a graduated embryo score accumulated over 72 hours and the expression of sHLA-G at 44-46 hours post fertilization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Self paying ART patients
排除标准
- •Abnormal uterus
- •Specific Immunologic factors
研究组 & 干预措施
A
Embryo selection for transfer based on a Day 3 score only.
干预措施: Human derived FSH (Drug)
B
Embryos for transfer by first selecting any embryos that had a positive sHLA-G expression of OD = 190 ±6 and correlating such with the highest GES score available.
干预措施: Human derived FSH (Drug)
结局指标
主要结局
Pregnancy and implantation rates
时间窗: 12 weeks
次要结局
- Miscarriage rates(9-11 day until βhCG)