Magnetoencephalography and High-Field Diffusion Tensor Magnetic Resonance Imaging of Neural Function and Connectivity in Traumatic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- Changes in white matter tract structure
研究概览
简要总结
The overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI) and that the impaired cortical activation can be detected with magnetoencephalography (MEG), and that the results of these imaging examinations will correlate with neurocognitive status and functional recovery after TBI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-50 years of age
- •single episode of blunt traumatic brain injury
- •symptoms of persistent post-concussive syndrome present an average of 4 months to 4 years since date of injury
- •fluency in English (cognitive battery not available in other languages)
- •capable of self-consent
排除标准
- •< 18 years or > 50 years of age
- •pregnancy
- •history of previous TBI with loss of consciousness
- •alcoholism as evidenced by Audit questionnaire
- •regular use of illicit drugs
- •non-English fluency
- •significant psychiatric history excluding mild depression or anxiety disorder any contraindication to MRI, including claustrophobia, pregnancy, any trauma or surgery which may have left ferromagnetic material in the body, ferromagnetic implants or pacemakers; and inability to lie still for 1 hour or more
结局指标
主要结局
Changes in white matter tract structure
时间窗: up to 4 years following date of injury
We believe that brain injury results in selective disruption of the associative white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI). We evaluate DTI using 3T and 7T MRI. Participants receive scans at only one time-point.
次要结局
- Neurocognitive function(up to 4 years following date of injury)
- Cortical activation(up to 4 years following date of injury)