The Influence of Different At-home Exercise Strategies on 24h Glycemic Control in Women at Risk for With Metabolic Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 107
- 试验地点
- 2
- 主要终点
- 24hr Glucose area under the curve
研究概览
简要总结
This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.
详细描述
Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •no cancer history
- •≥50 years old
- •Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score)
- •Owns a smartphone with Bluetooth capability with Apple or Android operating system
- •deemed safe to exercise as per the CSEP Get Active Questionnaire
- •Enrolled in NCT05454943
排除标准
- •Type 1 diabetes
- •Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists
- •Self-reported history of an eating disorder
- •BMI <18.5 kg/m
- •Working night or rotating shifts
- •Eating window <12 hours or consistently eating less than 3 meals/day in the past 3 months
- •Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)
结局指标
主要结局
24hr Glucose area under the curve
时间窗: 24 hours
Glucose area under the curve over 24hr
次要结局
- 24hr Average glucose concentration(24 hours)
- Time in hyperglycemia(24 hours)
- Postprandial dinner glucose response(2 hours)
- Nocturnal glucose(~6-8 hours)
- Postprandial breakfast glucose response(2 hours)
- Postprandial lunch glucose response(2 hours)
- Time in hypoglycemia(24 hours)
- Time in range(24 hours)
- Change in glucose during exercise(15-30 minutes)
- Standard deviation (SD)(24 hours)
- Continuous overall net glycemic action (CONGA)(24 hours)
- Mean amplitude glycemic excursion (MAGE)(24 hours)
- % coefficient of variation (CV)(24 hours)
研究者
Jenna Gillen
Assistant Professor
University of Toronto