Exploring the Long-term Effects of Cognitive Exercise on Cognition After Stroke
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Change from Baseline Flanker Effects at 10 weeks
研究概览
简要总结
This project will investigate the effectiveness of an intensive and focused working memory training program for chronic stroke patients. The investigators hypothesize that working memory training will be an effective method of improving working memory and related cognitive and behavioural functions in this population.
详细描述
Vascular cognitive impairment due to vascular disease and stroke frequently includes problems with attention, working memory and executive functions (e.g., monitoring, planning, and organization).
These deficits are common - 32-73%, and chronic, and interfere with a patients response to rehabilitation, independence in activities of daily living, community re-integration, and overall quality of life after stroke. Attention, memory and executive function impairments can adversely affect the ability to relearn various skills.
Cognitive impairments and their impacts on other components of functioning not only impact on the individual, but can also adversely affect the family via increases in caregiver distress and burden. Thus, the presence of cognitive impairment has wide-reaching impact and deserves effective and consistent intervention similar to the attention devoted to improving function in physical domains.
Cognitive training can improve cognitive function, particularly in those areas known to involved in vascular cognitive impairment, i.e., attentional and executive function. Accumulating evidence indicates that computer-based training can improve cognitive skills in healthy older adults as well as in clinical populations. Attention and working memory training has also been shown to be effective in patients in the chronic phase post stroke.
The investigators propose that specific cognitive training to improve working memory could provide direct benefit to chronic stroke patients. Promising interventions focused on intensive and direct working memory training are emerging and have been shown to generalize to other cognitive domains, such as fluid intelligence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects must: (i) be ≥18 years of age, (ii) have been received the diagnosis of ischemic or hemorrhagic stroke >6 months ago, (iii) be experiencing stroke-related cognitive problems that interfere with daily functioning, (iv) be able to perform a two-step command, (v) live within a 75 km radius of the Queen Elizabeth II
排除标准
- •Subjects must not: (i) have moderate or severe receptive aphasia, (ii) have a terminal illness, life-threatening co-morbidity or concomitant neurological or psychiatric illness.
研究组 & 干预措施
Variable Structured Cognitive Exercise
This training group will consist of 10 randomly assigned participants who will begin the adaptive working memory training task immediately after baseline assessment. Each participant will receive 30 minutes of cognitive exercise per day, 3 days a week for 10 weeks.
干预措施: Variable Structured Cognitive Exercise (Behavioral)
Constant Structured Cognitive Exercise
This training group will consist of 10 randomly assigned participants who will begin the adaptive working memory training task immediately after baseline assessment. Each participant will receive 30 minutes of cognitive exercise per day, 3 days a week for 10 weeks.
干预措施: Constant Structured Cognitive Exercise (Behavioral)
结局指标
主要结局
Change from Baseline Flanker Effects at 10 weeks
时间窗: The participants will be assessed on session 1 of week 1 and on session 31 of week 10
Flanker test \[primary study outcome\] is a computerized test of selective attention and reaction time that involves a motor response. The participant needs to focus and identify an item presented on a screen while ignoring task-irrelevant distracters. Performance on this test has been shown to improve with exercise
次要结局
- Change from Baseline Raven's Matrices Scores at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Change from Baseline Montreal Cognitive Assessment Scores at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Change from Baseline Networks of Attention Battery scores at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Change from Baseline Sternberg Digit Memory scores at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Change from Baseline Cognitive Failures Questionnaire Scores at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Change from Baseline Hospital Anxiety and Depression Scale (HADS) at 10 weeks(The participants will be assessed on session 1 of week 1 and on session 31 of week 10)
- Cognitive Activities Questionnaire and the Physical Activity Scale for the Elderly (PASE)(Participants will be assessed during the duration of the study, an expected average of 10 weeks)