NCT00790166终止不适用
Effects of nCPAP With and Without Humidification on: Inspiratory Temperature, Humidity, Saccharine Transit Time, Nasal Lavage and in Vitro Mucus Properties in Patients With Obstructive Sleep Apnea
Fisher and Paykel Healthcare1 个研究点 分布在 1 个国家目标入组 4 人开始时间: 2008年10月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- mucociliary clearance.
研究概览
简要总结
That the level of humidification delivered to patients during CPAP treatment will alter the subjects mucociliary clearance rate and related mucus properties.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Moderate to severe obstructive sleep apnea - Apnea Hypopnea Index (AHI) > 15
- •75% of events during the diagnostic study must be obstructive
排除标准
- •Currently using CPAP treatment OR have used it in the past 4 weeks
- •Intolerance of CPAP and/or CPAP mask in the past or during the titration night
- •Mouth breather (unable to breath through mouth for the study period)
- •< 18years old
- •Nasal CPAP intolerance determined in the PSG-CPAP titration study
- •Serious nasal issues
- •Acute upper airway disease
- •Congestive heart failure
- •Neuromuscular disease
研究组 & 干预措施
CPAP + Conventional humidity
Active Comparator
干预措施: CPAP + Conventional humidity (Device)
CPAP + No added humidity
Active Comparator
干预措施: CPAP + No added humidity (Device)
CPAP + ThermoSmart™ humidity
Active Comparator
干预措施: CPAP + ThermoSmart™ humidity (Device)
结局指标
主要结局
mucociliary clearance.
时间窗: pre and post cpap treatment with varying levels of humidity
次要结局
未报告次要终点
研究者
研究点 (1)
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