临床试验/NCT00938418

NCT00938418Unknown2 期

Phase II Study on Dose Escalated, Accelerated Hypofractionated Intensity Modulated Radiotherapy for Stage III Non-Small Cell Lung Cancer With Concurrent Chemotherapy

National University Hospital, Singapore2 个研究点分布在 1 个国家目标入组 43 人开始时间: 2009年7月最近更新: 2009年7月13日

适应症

试验速览

阶段: 2 期
发起方: National University Hospital, Singapore
入组人数: 43
试验地点: 2
主要终点: Overall survival

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Locally advanced non-small cell lung cancer can be treated successfully with chemotherapy and radiation. However, the cure rate is low.

This study is carried out to find out whether giving radiotherapy at a higher dose over fewer treatment sessions with intensity modulated radiotherapy (IMRT) can improve the treatment outcome.

This study aims to recruit 43 patients from National University Hospital and Tan Tock Seng Hospital over a period of about 2 years.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 21 Years 至 70 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Pathologically proven (either histologic or cytologic) diagnosis of Stage IIIA or IIIB non-small cell lung cancer; excluding patients with N3 disease based on supraclavicular or contralateral hilar adenopathy, or significant pleural / pericardial effusion.

排除标准

•Patients for whom treatment is planned with a maximum dose of ≥ 66 Gy to the ipsilateral brachial plexus
•Greater than minimal, exudative, or cytologically positive pleural effusions
•≥ 10% weight loss within the past month
•Prior invasive malignancy (with exceptions)
•Prior radiotherapy to the region of the study cancer
•Significant co-morbidities
•Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
•Known allergic reactions to components of planned chemotherapy regimen

结局指标

主要结局

Overall survival

时间窗: 2 years

次要结局

Response rate, locoregional control, disease free survival, toxicity(2 years)

研究者

发起方

National University Hospital, Singapore

申办方类型

Other

研究点 (2)

Loading locations...

相似试验

Unknown

1 期

Individual Boosting in Non-Small Cell Lung Cancer Using Hypofractionation, Intensity-modulated Radiation Therapy and Respiratory GatingCarcinoma, Non-Small-Cell Lung

NCT00690963AHS Cancer Control Alberta12

撤回

2 期

Combination of Platinum Doublets and Hypofractionated Radiotherapy in NSCLCNon-Small Cell Lung Cancer

NCT02947113The Netherlands Cancer Institute

招募中

2 期

Thoracic Radiotherapy for Patients With Metastatic (Stage IV) Non-Small Cell Lung Cancer at High Risk of Symptomatic Progression Within the ThoraxStage 4 NSCLCRadiotherapy

NCT06262321University of Rochester48

已完成

1 期

Study of Radiation Dose Intensity Concurrent With Chemotherapy For Limited Stage Small Cell Lung CancerCarcinoma, Small Cell

NCT00126828AHS Cancer Control Alberta18

尚未招募

不适用

Designing information for lung cancer patients in decision making.Patients presenting with a stage I non-small cell lung cancer (NSCLC).Patienten met stadium I niet kleincellige longkanker.

NL-OMON2116225