Effect of Exogenous Ketone Supplementation on Cognitive Function During Exercise After Induced Mental Fatigue
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Cognitive function
研究概览
简要总结
15 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Ketone esters supplementation and iso-caloric carbohydrate. The purpose of this study is to evaluate the effect of ketone esters on cognitive function during exercise after induced mental fatigue
详细描述
mental fatigue is often seen in sports of moderate to long duration. its onset is associated with detriments in cognitive function which leads to poor decision making and detriments in specific sport skills. Ketones can serve as a powerful brain fuel source so they may have the potential to delay/ revert the onset of mental fatigue. in this experiment, we will induce mental fatigue in individuals who will be performing 45 minutes of intermittent exercise right after. During exercise cognitive function will be measured under 2 condition, Ketone supplementation and placebo. The purpose of this study is to see if ketones can play a role in reverting that initial mental fatigue during exercise, compared to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
Participants and investigators will be blinded as an individual not involved in the project will assemble and distribute the treatment (drinks) according to a coding system that is kept confidential until the study is completed. Participants will complete the protocol twice and the treatment order will be systematically rotated to avoid any order effect. taste and texture of treatments will be matched and will be distribute in opaque bottles to keep participant blinded
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •In order to be eligible to participate in this study you must be a healthy male or female recreationally active individual, 18-35 year old.
排除标准
- •You will be excluded from this study if you:
- •Are not involved in regular exercise (at least 2x week)
- •Have symptoms or take medication for respiratory, cardiovascular, metabolic, neuromuscular disease
- •Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
- •Are taking part in another research study
- •For women, if you are pregnant or become pregnant during the study.
- •Have a history of concussion/head injuries.
- •Have an excessive alcohol intake (>2 drinks/day)
- •Are consuming a ketogenic diet (for at least 2 weeks)
- •Are a smoker
- •** Cannabis use is not a exclusion criteria; however, it must be avoided on experimental days.**
结局指标
主要结局
Cognitive function
时间窗: 30 minutes
participants will be doing the Stroop test and a complex reaction test during exercise.
次要结局
- Blood Glucose(45 minutes)
- Blood Ketones(45 minutes)
- Blood Lactate(45 minutes)
研究者
Peter Lemon
Professor
Western University, Canada