Anti-mullerian Hormone Levels in Healthy Females
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Anti-mullerian Hormone Levels in Healthy Females
研究概览
简要总结
The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development.
详细描述
Anti-mullerian hormone (AMH) is a chemical in the body that is found in the blood that can estimate the ability of a female to have her own children. It is widely used in adult female cancer patients to predict the onset of menopause and/or the inability to have children that can be associated with chemotherapy and/or radiation treatment. Normal blood levels of AMH are better understood in adults than in children and adolescents. The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development. With a better understanding of normal AMH levels in children, we may be able to better assess a girl's risk of not being able to have children if she is a cancer patient, and may be able to offer her and her family options to increase the chances of having her own children.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pre- and post-pubertal females
- •Ages 0-18 years old
- •Tanner Stage I- V
- •Undergoing routine outpatient surgical procedure
- •Hernia repair (inguinal, umbilical, epigastric)
- •Excision of benign mass
- •laparoscopic cholecystectomy
排除标准
- •Previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) or endocrine disorder associated with irregular menstrual cycles (Cushing's disease, poorly-controlled Thyroid disease, hyperprolactinemia, polycystic ovary syndrome, and congenital adrenal hyperplasia) or insulin-dependent diabetes mellitus or autoimmune disorders
- •Previous diagnosis of any malignancy or any history of systemic/local chemotherapy, radiation therapy, or stem-cell transplant.
- •Previous surgical excision of one ovary or both ovaries
- •Pregnant females
- •All inpatient surgical patients
- •Undergoing non-routine outpatient surgical procedures
- •Central venous catheter placement
- •Supprelin insertion/removal
- •Breast mass excision
- •Gastrostomy tube insertion
研究组 & 干预措施
Blood sample collection
Blood samples are collected for diagnostically assessing how the blood AMH levels correspond to a female's reproductive development
干预措施: Blood sample collection (Diagnostic Test)
结局指标
主要结局
Anti-mullerian Hormone Levels in Healthy Females
时间窗: 3 Years
The primary outcome measure is to get a better understanding of the normal AMH levels in children (girls aged 0-18 years) in order to better assess a girl's risk of not being able to have children if she is a cancer patient, and in offering her and her family options to increase the chances of having her own children
次要结局
未报告次要终点
研究者
Erin Rowell
Director
Ann & Robert H Lurie Children's Hospital of Chicago