The Role of the Inferior Frontal Gyrus in Long-Term Auditory Memory a rTMS Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- The primary outcome of this study is the error rate during the recognition memory task. The error rate is defined by the amount of stimuli that are correctly classified as familiar or unfamiliar.
研究概览
简要总结
Background:
- Studies have shown that animals such as monkeys and dogs have excellent sight and touch memory but perform poorly on sound memory tasks. Human brains have certain areas that are important for speaking and understanding language. These areas may be involved in sound and spoken word memory. Researchers want to study these areas of the brain to find out if the memory for sounds requires brain structures that are usually associated with language learning and are unique to humans.
Objectives:
- To use magnetic resonance imaging to study areas of the brain involved in sound memory.
Eligibility:
- Healthy right-handed volunteers between 18 and 50 years of age. They must be native English speakers and have completed high school.
Design:
- The study requires a screening visit and 1 or 2 study visits to the National Institutes of Health Clinical Center.
- At the screening visit, volunteers will have a medical history taken. They will also have physical and neurological exams, and complete a questionnaire. Women of childbearing age will give a urine sample. Participants who have not had a magnetic resonance imaging (MRI) scan in the past year will have one at this visit.
- At the second visit, participants will have tests of sound memory. They will listen to a set of nonsense words spoken through earphones and memorize the words. Then they will listen to the words again to judge if the words were part of the earlier list. Participants will have a 1 hour break, then do the sound memory test again. During the second test they will have repetitive transcranial magnetic stimulation (rTMS), which stimulates different regions of the brain.
- If the group results from the testing sessions are positive, there will be a third visit. At this visit, participants will have a sound perception test. They will listen to words spoken through earphones and judge whether the words in the pair are the same or different. Participants will have rTMS during these tests as well.
详细描述
Objective:
Humans are the only animals that use language to communicate with each other. Among many other requirements, humans need excellent auditory long-term memory to be able to master the complicated task of learning a language. It is still not completely understood which brain regions are involved in transferring auditory stimuli into long-term memory. The goal of this research proposal is to examine whether brain structures that are known to be essential in language production also play an important role in encoding auditory stimuli into long-term memory.
Study population:
We propose using repetitive transcranial magnetic stimulation (rTMS) to examine the role of
frontal and temporo-parietal cortical areas in the storage of auditory stimuli in long-term memory. The whole study will comprise three experiments. Each of the three experiments will consist of one to three sessions. Sessions 1 and 2 will be compulsory in every experiment. Session 3 will only be required if positive results are obtained in session 2. Every participant can only participate in one of the three planned experiments.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
The primary outcome of this study is the error rate during the recognition memory task. The error rate is defined by the amount of stimuli that are correctly classified as familiar or unfamiliar.
次要结局
- The secondary outcome measure of this study is the reaction time of participants to make judgments concerning the familiarity during the recognition memory task.