Construction of a Cohort for Pan-Vascular Disease Among Employees of Taizhou People's Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 主要终点
- Cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke events
研究概览
简要总结
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Participant Recruitment During the annual health check-ups for hospital staff, potential participants are recruited. Those who express interest are provided with a detailed explanation of the study's objectives, content, and procedures, and are required to sign an informed consent form.
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Screening Phase Medical history is collected, including any previous occurrences of myocardial infarction, ischemic or hemorrhagic stroke, or history of coronary, carotid, or peripheral arterial revascularization.
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Baseline Data Collection
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Health Questionnaire Survey: Collect demographic information, medical history, and data on nutrition, physical activity, and smoking habits through a questionnaire.
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Clinical Assessments: Conduct the following assessments for all enrolled participants:
- High-sensitivity cardiac troponin I and NT-proBNP testing
- Non-invasive arterial stiffness testing
- Measurement of visceral and subcutaneous fat content
- Fundus photography
- Body composition analysis
4 Regular Follow-Up
Annual follow-up for a total of 10 years. The follow-up includes:
- . Collection of updated demographic information and medical history, as well as repeated questionnaires on nutrition, physical activity, and smoking habits.
- . Reassessment of the following items:
- High-sensitivity cardiac troponin I and NT-proBNP testing
- Non-invasive arterial stiffness testing
- Measurement of visceral and subcutaneous fat content
- Fundus photography
- Body composition analysis
5 Outcome Evaluation
1）. Primary Outcomes: Cardiovascular mortality, non-fatal myocardial infarction, or non-fatal stroke events.
2）. Secondary Outcomes: All vascular events, changes in cardiovascular biomarkers, and degree of arterial stiffness.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Employed or retired individuals aged 45 years or older;
- •Willing to sign an informed consent form and voluntarily participate in health examinations and related data collection.
排除标准
- •History of myocardial infarction, ischemic or hemorrhagic stroke, or revascularization of coronary, carotid, or peripheral arteries;
- •Employees with severe psychological disorders who are unable to cooperate with the study;
- •Pregnant or breastfeeding women.
结局指标
主要结局
Cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke events
时间窗: September 2024 to August 2034
Cardiovascular death: Death from heart or blood vessel diseases. Non-fatal myocardial infarction: Heart attack that does not result in death. Non-fatal stroke events: Stroke incidents that do not result in death.
次要结局
未报告次要终点