Functional Connectivity (With fMRI) as an Objective Measure of Postoperative Cognitive Function in Elderly Fracture Hip Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Changes between baseline and follow up visits as assessed by fMRI
研究概览
简要总结
The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
详细描述
In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 99 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 65 years and older
- •Patients who have fracture hip and are anticipated to have surgery
排除标准
- •Patients who have contraindications for MRI like pacemaker, automatic implanted cardiac defibrillator (AICD), implanted infusion pumps etc.
- •Patients who are claustrophobic
- •Patients with severe cognitive impairment (who may not be able to cooperate during the cognitive exam and fMRI)
研究组 & 干预措施
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: fMRI (Behavioral)
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: Montreal Cognitive Assessment (MoCA) (Behavioral)
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: Digital Clock Drawing Test Command and Copy (Behavioral)
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: Wide Range Achievement Test reading subtest (Behavioral)
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: Hopkins Verbal Learning Test (HVLT) (Behavioral)
Elderly Hip Fracture
Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
干预措施: General Depression Scale (GDS) (Behavioral)
结局指标
主要结局
Changes between baseline and follow up visits as assessed by fMRI
时间窗: Change from baseline up to 90 days
fMRI for measuring function connectivity and DTI
次要结局
- Changes between baseline and follow up visits as assessed by Digital Clock Drawing Test Command and Copy(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by Wide Range Achievement Test reading subtest(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by MoCA(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by HVLT(Change from baseline up to 90 days)