Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery: Risk Factor Analysis, Impact on Clinical Outcomes and Development of Prediction Model
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,400
- 试验地点
- 1
- 主要终点
- The predictive performance of the model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery
研究概览
简要总结
The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery.
The main questions it aims to answer are:
- To validate the predictive performance of the model for PMV after ATAAD surgery
- To assess the proportion of PMV among patients undergoing ATAAD surgery
- To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 18 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years;
- •Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;
- •Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.
排除标准
- •Reintubation;
- •Intraoperative death or failure to survive beyond 72 hours postoperatively;
- •Pregnancy;
- •Severe comorbidities (e.g., lung cancer);
- •Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).
结局指标
主要结局
The predictive performance of the model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery
时间窗: 72 hours after ATAAD surgery
The predictive performance of PMV following ATAAD surgery includes its discriminative ability and calibration ablility.
The proportion of patients with PMV
时间窗: 72 hours after ATAAD surgery
The proportion of patients with PMV refers to the proportion of patients with PMV among the total included ATAAD postoperative patients. PMV is defined as postoperative mechanical ventilation lasting more than 72 hours
次要结局
- ICU length of stay (ICU-LOS)(From surgery to discharge or death, whichever came first, assessed up to 6 months)
- surgery-related mortality(30 days after ATAAD surgery)
研究者
Gang Hou
Professor
China-Japan Friendship Hospital