NL-OMON41819已完成不适用
euro-cognitive effects of tyrosine supplementation in healthy older adults: <br>A fNIRS-EEG study<br> - INTENSE
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •- Aged 60-75 years
- •- Right-handed
- •- Dutch speaking
- •- Normal or corrected to normal vision
排除标准
- •- Mini-Mental State Examination (MMSE) score of <24
- •- Estimated IQ of <85 (based on Nederlandse Leestest voor Volwassenen (NLV) -score)
- •- Hospital Anxiety and Depression Scale score of >11
- •- Current or past psychiatric disorder, such as psychosis or major depression
- •- Current or past neurological disorder, such as severe cerebral vascular disease (e.g. cortical stroke, subarachnoid hemorrhage), Parkinson*s disease, epilepsy, traumatic brain injury, central nervous system infection, brain tumor, and alcoholic encephalopathy. N.B. Transient Ischaemic Attack, lacunar infarction and white matter lesions are no exclusion criteria.
- •- Current severe systemic disease such as coronary artery disease, myocardial infarction < 6 months, heart failure (unstable), chronic obstructive pulmonary disease (unstable)
- •- Current endocrine or metabolic disorders such as hepatic or renal problems
- •- First degree family history of schizophrenia, bipolar disorder or major depressive disorder
- •- Thyroid problems, such as hyperthyroidism, subclinical hyperthyroidism (TSH <0.4 mU/L), hypothyroidism, thyroid cancer
- •- Using medication that can interfere with tyrosine*s action: monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
- •- Following a low-protein diet as prescribed by a dietician or physician
- •- Use of tyrosine supplements within one month prior to visit
- •- Being allergic or having a dislike to the product carrier (banana-flavored yoghurt)
- •- Blood pressure < 90/60 mmHg or > 160/90 mmHg (use of antihypertensives are allowed)
- •- General medical conditions, such as repetitive strain injury (RSI), colorblindness or sensori-motor handicaps, which may confound the results of the study, as judged by the investigator
- •- Alcohol consumption of more than 14 (women) or 21 (men) units per week
- •- Habitual smoking, defined as more than a pack of cigarettes per week
- •- Current participation in another study, or a specific cognitive training study within the past six months, or a study using the same cognitive paradigm as the current study
研究者
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