Evaluation of Hair Changes in Female Patients With Type2 Diabetes Mellitus Versus Non-Diabetic Controls :A Clinical and Dermoscopic Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Evaluation of Hair Changes in Female Patients with Type 2 Diabetes Mellitus Versus Non-Diabetic Controls: A Clinical and Dermoscopic Cross-Sectional Study
研究概览
简要总结
The aim of this thesis is to investigate the effect of diabetes mellitus on hair by assessing and comparing clinical and dermoscopic hair changes in diabetic patients versus age and sex-matched healthy controls.
详细描述
The patients will be recruited from the dermatology and endocrinology outpatient clinics of Al-Zahraa University Hospital.
Inclusion criteria •
Cases:
Female patients aged 20-60 years Diagnosed with type 2 diabetes mellitus for at least 1 year HbA1c ≥ 6.5% o Consent to participate
- Controls:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients aged 20-60 years
- •Diagnosed with type 2 diabetes mellitus for at least 1 year
- •HbA1c ≥ 6.5% o Consent to participate
- •Controls:
- •Age-matched healthy females (no history of diabetes or insulin resistance)
- •Normal fasting blood sugar (<100 mg/dL) and HbA1c (<5.7%) o No known chronic illness
- •Consent to participate
排除标准
- •Current pregnancy or lactation
- •Thyroid dysfunction • Polycystic ovary syndrome (PCOS)
- •Anemia (Hb < 10 g/dL)
- •History of chemotherapy, radiotherapy, or recent acute illness
- •Scalp diseases (e.g., tinea capitis, scarring alopecia)
- •Recent use of drugs known to affect hair growth (e.g., isotretinoin, spironolactone)
结局指标
主要结局
Evaluation of Hair Changes in Female Patients with Type 2 Diabetes Mellitus Versus Non-Diabetic Controls: A Clinical and Dermoscopic Cross-Sectional Study
时间窗: 1 year
Clinical Hair Assessment: 1. Hair loss pattern (diffuse, frontal, vertex, etc.) 2. Duration of hair loss (months/years) 3. Hair pull test results (positive/negative) Dermoscopic (Trichoscopic) Features: 1. Hair shaft diameter variability (%) 2. Presence of yellow dots, white dots, or peripilar signs 3. Follicular density (number/cm²) 4. Miniaturized hair count Metabolic and Laboratory Parameters: 1. BMI (kg/m²) 2. HbA1c (%) 3. Serum Ferritin (ng/mL) 4. Vitamin D3 (ng/mL) 5. TSH (µIU/mL) 6. Hemoglobin (g/dL) 7. ESR (mm/hr) Diabetes-Related Measures: 1. Duration of diabetes (years) 2. Presence of diabetic neuropathy (yes/no) Patient-Reported Outcomes Visual Analog Scale (VAS) for hair loss severity (ludwing scale-sinclair scale) Physician's Global Assessment of hair changes
次要结局
未报告次要终点
研究者
Heba Khaled Younes Mohamed
resident
Al-Azhar University