Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Apnea-Hypopnea Index (AHI)
研究概览
简要总结
This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake.
Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Right-handed, English-speaking adults, 18-60 years old who report normal hearing during sleep
- •Participants with suspected obstructive sleep apnea (OSA) (including those who have been diagnosed by a physician and those whose self-reported symptoms of OSA on the STOP-BANG questionnaire classify them as being "individuals with intermediate to high risk".
- •No report of any other sleep disorder besides OSA.
- •No report of any neurological or cardiometabolic diseases or disorders.
- •Not currently under active treatment for sleep apnea.
排除标准
- 未提供
研究组 & 干预措施
All participants
干预措施: Wake training + TMR (Behavioral)
结局指标
主要结局
Apnea-Hypopnea Index (AHI)
时间窗: Day 1
AHI indexes the severity of OSA on the night of the study.
Respiratory event duration
时间窗: Day 1
The duration of a hypopnea or apnea on the night of the study.
次要结局
未报告次要终点
研究者
Ken Paller
Professor
Northwestern University