The Effect of Respiratory and Aerobic Exercises on Neuroprotective and Inflammation Biomarkers in Patients Diagnosed With Major Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Oxidative stress biomarkers
研究概览
简要总结
This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals who volunteer to participate in the study,
- •Between the ages of 18 and 40,
- •Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria
排除标准
- •Individuals with chronic conditions accompanying depression,
- •Those with walking difficulties
- •Those with respiratory system disorders
研究组 & 干预措施
Exercise Group
Those included in the experimental group continued diaphragmatic breathing exercises every day for three weeks and walking exercises at least three days a week.
干预措施: Aerobic Exercise (Other)
Control group
The control group continued their routine lives, and at the end of three weeks
Exercise Group
Those included in the experimental group continued diaphragmatic breathing exercises every day for three weeks and walking exercises at least three days a week.
干预措施: Breathing exercise (Other)
结局指标
主要结局
Oxidative stress biomarkers
时间窗: From enrollment to the end of treatment at 3 weeks
It has been reported that the interaction between oxidative stress and the immune system is important, and that activated immune inflammatory pathways can trigger oxidative stress. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of oxidative stress (TAS, TOS, MDA, and F2-isoprostane) biomarkers, which play a role in the pathophysiology of depression.
Proinflmatuar sytokines
时间窗: From enrollment to the end of treatment at 3 weeks
It is believed that increased production of key proinflammatory cytokines such as interleukin tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1) and acute phase reactants plays an important role in the development of depression as a result of immune system involvement. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of inflammation (TNF-α, IL-6, IL-1) which play a role in the pathophysiology of depression.
次要结局
未报告次要终点