EUCTR2008-002169-30-GB进行中（未招募）1 期
A randomised placebo-controlled trial of metformin on progression of carotid atherosclerosis in non-diabetic patients with cardiovascular disease treated with conventional risk reducing agents - CAMERA: Carotid Atherosclerosis: MEtformin for insulin ResistAnce study
Greater Glasgow Health Board, Research and Development Department0 个研究点目标入组 220 人开始时间: 2008年10月9日最近更新:
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 220
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •oProven coronary heart disease (prior acute coronary syndrome, prior coronary artery bypass graft or angiographically proven coronary heart disease)
- •oAged 35-75 years
- •oElevated waist circumference as per the International Diabetes Foundation criteria (94cm in men and 80cm in women)
- •oAttending Cardiology outpatient clinics at Glasgow Royal Infirmary, the Western Infirmary, Stobhill Hospital and Royal Alexandra Hospital ; and patients identified at volunteering GP surgeries in Glasgow as approved by the Scottish Primary Care Research Network
- •oAll patients will be on statin medication.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •oPregnancy and/or lactation at screening
- •oPremenopausal woman not on adequate contraception (defined as daily oral hormonal contraception or regular injectable hormonal contraception)
- •oKnown or newly diagnosed diabetes mellitus on oral glucose tolerance testing (OGTT will be performed on subjects with HbA1C 6.0-6.9% and fasting plasma glucose <7.0mmol/L at screening)
- •oScreening results: HbA1C =7.0% and/or fasting plasma glucose =7.0mmol/L
- •oPatients with acute coronary syndrome within the last 3 months
- •oStage 3 or 4 heart failure defined according to the New York Heart Association criteria
- •oUncontrolled angina
- •oContraindications to metformin (example hepatic impairment, renal impairment [eGFR <45 mL/min/1.73m2 at screening], known hypersensitivity to metformin, acute illness [dehydration, severe infection, shock, acute cardiac failure]), and suspected tissue hypoxia will be excluded.
研究者
相似试验
进行中（未招募）
不适用
A Prospective Randomised Pilot Study of Metformin and Lifestyle Intervention in the Prevention of Metabolic Syndrome due to Androgen Deprivation Therapy in Prostate Cancer - Metformin use in patients on ADT to prevent Metabolic SyndromePatients with prostate cancer on androgen deprivation therapy (ADT). Randomisation between standard treatment with ADT only, and the additional use of metformin with dietary and exercise advice.Aim is to reduce the prevalence of metabolic syndrome in the intervention arm - this is a condition linked to ADT in prostate cancer patientsMedDRA version: 9.1Level: LLTClassification code 10001186Term: Adenocarcinoma of prostateMedDRA version: 9.1Level: LLTClassification code 10052066Term: Metabolic syndromeEUCTR2007-002815-20-GBRoyal Surrey County Hospital
进行中（未招募）
1 期
Clinical pilot study on the effect of Metformin in adipose children and adolescents with insulin-resistanceKlinische Pilotstudie zur Untersuchung der Wirkung von Metformin bei adipösen Kindern und Jugendlichen mit Insulin-Resistenz (IR) - not availableInsuline-resistance in adipose children and adolescentsEUCTR2004-003816-47-DEPädiatrische Endokrinologie, Universitätsmedizin Berlin, Charité
进行中（未招募）
1 期
A randomised study of the effect of metformin and exercise in overweight women with polycystic ovary syndrome - Metformin-exercise projectPolycystic ovary syndrome is a condition characterized by obesity, anovulation and hyperandrogenism/hyperandrogenemia. Insulin resistance is common, and treatment is aimed at reducing this.EUCTR2004-004257-26-DKOrganisation name was not entered
进行中（未招募）
1 期
A randomised controlled clinical trial of metformin versus orlistat for the management of obses anovulatory women - n/aEUCTR2005-002096-32-GBSheffield Teaching Hospitals NHS Foundation Trust
进行中（未招募）
1 期
Prevention of chronic diseases through diet and metformiEUCTR2012-005427-32-ITFondazione IRCCS Istituto Nazionale dei Tumori2,000