Prospective multicenter study of the effectiveness of NBI magnified endoscopy with acetic acid for the diagnosis of histological type of early gastric cancer. - Acetic acid NBI study

Histological types of target areas were wel, mod and poor in 166, 40 and 15 cases, respectively. The sensitivity of wel, mod and poor by WL, NBI-ME and NBI-AA were 99.4% (165/166), 89.6% (149/166) and 94.6% (157/166) in wel, 0% (0/40), 20% (8/40) and 12.5% (5/40) in mod and 60% (9/15), 60% (9/15) and 60% (9/15) in poor, respectively. There were no significant differences. Sub-analysis: The diagnostic accuracy by surface pattern in NBI-ME was 100% (20/20) in pit pattern, 78.9% (120/152) in villous pattern and 53.1% (26/49) in unclear pattern. And NBI-AA changed these diagnostic accuracy 100% (20/20), 78.3% (119/152) and 65.3% (32/49) respectively. While the diagnostic accuracy by unclear pattern in NBI-ME was low compared to other surface patterns, NBI-AA improved it from 53.1% to 65.3%.