Clinical, Pharmacological and Biological Investigations of a Polymorphism of Nedd4 , a Regulatory Protein of the Epithelial Sodium Channel
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 219
- 主要终点
- Difference in Blood Pressure among genotypes
研究概览
简要总结
Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of Nedd4 and in turn, the ability of kidneys to excrete salt intake. Our hypothesis is that the genetic variants of Nedd4.2 could constitute a genetic predisposition to (or protection against) salt-sensitive hypertension.
详细描述
Subjects were submitted one week to a low sodium-high potassium diet, and then switch to a high sodium,-low potassium diet for two weeks. the last week, subject were taken a 20 MG daily dose of amiloride, a potassium sparing diuretic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
- •between 18 and 35 years odl
- •BMI between 18 and 28 Kg per m2
- •non smokers
- •no active disease
- •no alcool or drug abuse
排除标准
- 未提供
结局指标
主要结局
Difference in Blood Pressure among genotypes
时间窗: 24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks
24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks
次要结局
- Ambulatory Blood Pressure (AMBP)(three weeks)