ISRCTN46322781已完成1 期
Acute and long-term effects of endocannabinoid modulation in individuals at high risk for psychosis: an experimental study
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 33
研究概览
简要总结
2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30167644 results 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32921794/ (added 08/11/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 18- 35 years
- •2. Right-handed
- •3. Ultra high risk (UHR) for psychosis individuals being supported by OASIS (https://www.oasislondon.com), a large clinical service for this group
- •4. Have positive psychotic symptoms and anxiety symptoms, as defined using the Positive and Negative syndrome scale (PANSS) and the State-Trait Anxiety Inventory (STAI)
- •5. Medication naïve
排除标准
- •1. History of previous psychotic disorder or manic episode
- •2. Current DSM IV diagnosis of substance dependence (except cannabis dependence)
- •3. Neurological disorders (eg., epilepsy) or severe intercurrent illness that may put the person at risk
- •4. IQ of less than 70
- •5. Female subject who is unwilling to use two forms of contraception (one of which must be a barrier contraception), pregnant, lactating or planning pregnancy during the course of the study and 3 months from the date of the last dose and a male subject whose partner is of child-bearing potential and unwilling to use a barrier method of contraception along with their partner
研究者
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