Study of Cerebral Mechanisms of Visual Recognition With Single-unit Recordings of Intra-cerebral Neurons in Epileptic Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Number of action potential (Difference of neuronal activity) generated successively by visual presentation of 60 photography of different unknown faces and 60 different objects
研究概览
简要总结
The purpose is to evaluate specific capacities of face detection of individual neurons by comparison with their capacity of object detection in medial temporal lobe and ventral temporal cortex in epileptic patients.
Secondary purpose is to evaluate specific capacities of detection of known faces of individual neurons by comparison with their capacity of detection of unknown faces in medial temporal lobe and ventral temporal cortex in epileptic patients.
详细描述
In this interventional study, patients explored with mixed intracerebral electrodes (micro and macro-contacts) will be presented sets of images (objects, unknown faces, famous faces). Spikes and Multi-Unit-Activity will be recorded and analyzed and compared between conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with temporal or occipito-temporal drug-resistant partial epilepsy, symptomatic, needing surgical treatment
- •Patient having signed informed consent
- •Patient affiliated to social security
- •Patient having undergone preliminary medical examination
排除标准
- •Persons under legal protection or incapable to consent
- •Persons deprived of liberty by juridical or administrative decision
- •Patient with severe visual disorders of neurological or ophthalmological origin
- •Patients with infection risk according to doctor or surgeon
- •Women without effective contraception
- •Pregnant or breast-feeding women
结局指标
主要结局
Number of action potential (Difference of neuronal activity) generated successively by visual presentation of 60 photography of different unknown faces and 60 different objects
时间窗: after electrode implantation, up to 12 days
Activity (number of action potential) is recorded for each neuron before and after visualization of each image.
次要结局
- Number of action potential (Difference of neuronal activity) generated by visual presentation of 60 photography of a known target face (familiar) and 60 photography of unknown faces (non familiar)(after electrode implantation, up to 12 days)