Influence of CYP1A2 on the Prolonged Effect of Caffeine Intake on Resistance Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Mean velocity at different %1RM
研究概览
简要总结
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the prolonged effects of caffeine on this type of exercise.
Objectives: The present study aims to analyze the prolonged effects of caffeine intake on neuromuscular adaptations to resistance training according to CYP1A2 polymorphism in men and women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
Statistician
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between ≥ 18 and ≤ 35 years.
- •Body mass index (BMI) lowe than 25 kg/m².
- •Physically active subjects (≥ 150 min/week of moderate exercise).
- •Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
- •Participants capable of performing the tests.
排除标准
- •History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
- •Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
- •Body mass index (BMI) ≥ 25 kg/m².
- •Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
- •Performing strenuous exercise within 48 hours prior to the tests.
- •Failing to replicate the same food intake on the two experimental days.
- •Consuming caffeine after 6 PM on the day prior to training or testing.
研究组 & 干预措施
Genotype AA - Male - Caffeine
干预措施: Caffeine and Resistance training (Dietary Supplement)
Genotype AC or CC - Male - Caffeine
干预措施: Caffeine and Resistance training (Dietary Supplement)
Genotype AA - Male - Placebo
干预措施: Placebo and Resistance training (Dietary Supplement)
Genotype AC or CC - Male - Placebo
干预措施: Placebo and Resistance training (Dietary Supplement)
Genotype AA - Female - Caffeine
干预措施: Caffeine and Resistance training (Dietary Supplement)
Genotype AC or CC - Female - Caffeine
干预措施: Caffeine and Resistance training (Dietary Supplement)
Genotype AA - Female - Placebo
干预措施: Placebo and Resistance training (Dietary Supplement)
Genotype AC or CC - Female - Placebo
干预措施: Placebo and Resistance training (Dietary Supplement)
结局指标
主要结局
Mean velocity at different %1RM
时间窗: Through study completion, an average of 12 weeks
Measuring bar mean velocity desplacement during bench press and back squat exercises.
Peak velocity at different %1RM
时间窗: Through study completion, an average of 12 weeks
Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Mean power output at different %1RM
时间窗: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Peak power output and time to reach peak power output at different %1RM
时间窗: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Number of repetitions performed at 65%1RM until task failure
时间窗: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
时间窗: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failure
时间窗: Through study completion, an average of 12 weeks
In bench press and back squat exercise
Resting Metabolic Rate (RMR)
时间窗: Through study completion, an average of 12 weeks
Kcal at rest using a metabolic chart.
Maximal Fat Oxidation Rate (MFO)
时间窗: Through study completion, an average of 12 weeks
g/min (MFO) using a metabolic chart.
次要结局
- Fat-free mass(Through study completion, an average of 4 weeks)
- Fat mass(Through study completion, an average of 12 weeks)
- Physical activity (METs-min/wk)(Through study completion, an average of 12 weeks)
- Dietary (g/kg of macronutrients)(Through study completion, an average of 12 weeks)
- Mood state(Through study completion, an average of 12 weeks)
- Adverse effects(Through study completion, an average of 12 weeks)
研究者
Alberto Pérez-López
Principal Investigator
University of Alcala