Association Between Vitamin D Deficiency and Disease Activity in Patients With Inflammatory Bowel Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Prevalence of vitamin D deficiency in patients with active inflammatory bowel disease
研究概览
简要总结
Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods.
In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD.
Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D.
Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported.
Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases.
In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence.
In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged ≥18 years
- •Diagnosed with crohn's and ulcerative colitis
- •Regular follow-up in IBD clinic
- •Recent vitamin D and disease activity assessment (within 1 month)
排除标准
- •Current vitamin D supplementation(>1000IU/day)
- •History of malabsorption syndromes (e.g.,celiac disease)
- •Chronic kidney or liver disease
- •Pregnancy
结局指标
主要结局
Prevalence of vitamin D deficiency in patients with active inflammatory bowel disease
时间窗: Recent vitamin D and disease activity assessment (within 1 month)
This will be done by measuring the vitamin D level in the serum of patients with active inflammatory bowel diseases (in nanograms/ milliliter)
次要结局
未报告次要终点
研究者
Ahmed Mahmoud Hamed Gadelrab
principal investigator
Assiut University