Thioredoxin Reductase 1 Levels in Gingival Tissue as an Oxidative Stress Biomarker in Periodontitis

Ataturk University1 个研究点分布在 1 个国家目标入组 60 人开始时间: 2023年8月30日最近更新: 2026年5月20日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Ataturk University
入组人数: 60
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1), glutathione (GSH), and malondialdehyde (MDA), in gingival tissue samples collected from healthy individuals and patients with different stages of periodontal disease. The goal is to determine if TrxR1 levels can serve as a potential biomarker for diagnosing the severity and activity of periodontitis.

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 70 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Being between the ages of 18 and
•Having no known systemic disease.
•Non-smokers.
•No history of medication or supplement use in the last 3 months.
•For the Periodontitis groups: Interdental clinical attachment loss (CAL), probing pocket depth (PPD), and radiographic bone loss according to 2017 World Workshop criteria.

排除标准

•Pregnancy or breastfeeding.
•Presence of a systemic disease (e.g., diabetes mellitus, hypertension, rheumatoid arthritis, cancer, thyroid disorders, kidney or lung diseases).
•History of any periodontal surgical procedure within the last 6 months.
•Use of medication or supplements within the last 3 months.

研究者

发起方

Ataturk University

申办方类型

Other

责任方

Principal Investigator

主要研究者

Fuat Cetinkaya

PhD Student

Ataturk University

研究点 (1)

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