Effect of a Beetroot-based Nutritional Gel on Vascular Function and Forearm Muscle Oxygenation Responses in the Elderly at Cardiometabolic Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 主要终点
- Changes in the arterial stiffness as evaluated by the peak wave velocity.
研究概览
简要总结
Aging has been associated with reduced bioavailability of nitric oxide (NO) and endothelial dysfunction. Beetroot consumption, a nitrate-rich food, has been associated with increased NO bioconversion, which may promote beneficial effects on vascular health. The present study evaluated the effects of a beetroot-based nutritional gel (BG) on vascular function, arterial stiffness and blood pressure in the elderly at cardiometabolic risk. Twenty elderly individuals were submitted to BG and nitrate-depleted gel (PLA) interventions. Brachial flow-mediated dilation (FMD), blood flow velocity (BFV), peak wave velocity (PWVβ), augmentation index (AI), stiffness parameter (β), pressure-strain elasticity modulus (Ep), arterial compliance (AC), muscle oxygenation and function were measured 90 min after interventions. Urinary nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline, 90 min and 150 min after interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elderly participants (≥ 65 years)
- •Taking between 1 and 3 anti-hypertensive medications for high blood pressure;
- •Elevated triglycerides ≥ 150 mg/dL;
- •Reduced HDL-cholesterol < 50 mg/dL for women and < 40 mg/dL for men;
- •Elevated waist circumference by population definition (male: > 102 cm and female: > 88 cm).
排除标准
- •elevated fasting glucose (≥ 100 mg/dL), smoking, beetroot allergy, unwillingness to avoid beetroot products during the entire study, other chronic diseases (diabetes, liver disease, etc.), or acutely ill.
研究组 & 干预措施
Beetroot gel (dietary nitrate)
Beetroot-based nutritional gel containing approximately 10.0 mmol of nitrate per dose
干预措施: Beetroot-based nutritional gel (Other)
Placebo gel (nitrate-depleted)
Nutritional gel nitrate-depleted
干预措施: Placebo (Other)
结局指标
主要结局
Changes in the arterial stiffness as evaluated by the peak wave velocity.
时间窗: Evaluated 120 min after the nutritional intervention
Changes in endothelial function as evaluated by the flow-mediated dilation.
时间窗: Evaluated 120 min after the nutritional intervention
Changes in endothelial function as evaluated by blood flow velocity
时间窗: Evaluated 120 min after the nutritional intervention
Changes in the arterial stiffness as evaluated by the stiffness parameter
时间窗: Evaluated 120 min after the nutritional intervention
Changes in endothelial function as evaluated by reactive hyperemia.
时间窗: Evaluated 120 min after the nutritional intervention
Changes in the muscle oxygenation as evaluated by the levels of deoxygenated hemoglobin
时间窗: Evaluated 150 min after the nutritional intervention
Changes in the clinical blood pressure
时间窗: Evaluated before, 120 min and 180 min after the nutritional intervention
Changes in the muscle oxygenation as evaluated by the levels of oxygenated
时间窗: Evaluated 150 min after the nutritional intervention
Changes in the muscle function as evaluated by the maximal voluntary contraction of the forearm muscle
时间窗: Evaluated before and 180 min after the nutritional intervention
Changes in the arterial stiffness as evaluated by augmentation index
时间窗: Evaluated 120 min after the nutritional intervention
Changes in the arterial stiffness as evaluated by the pressure-strain elasticity modulus
时间窗: Evaluated 120 min after the nutritional intervention
Changes in the arterial stiffness as evaluated by the arterial compliance.
时间窗: Evaluated 120 min after the nutritional intervention
次要结局
未报告次要终点
研究者
Thiago Alvares
D.Sc.
Universidade Federal do Rio de Janeiro