Comparison of Cardiac Computed Tomographic Angiography (CTA) to Tc-99m Single Photon Emission Computed Tomography (SPECT)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 107
- 试验地点
- 2
- 主要终点
- To measure the accuracy of CTA to SPECT for the diagnosis of CAD
研究概览
简要总结
Cardiovascular disease and ischemic heart disease is the #1 killer in Canada. Currently, Cardiac invasive catheterization angiography (CICA) is the gold standard for the assessment of the arteries in the heart. However, cardiac catheterization has risks which prohibit its use in all patients. These risks include: death, heart attack, stroke and bleeding. Cardiac computed tomography angiography (CTA) is a new non-invasive technology which may enable the evaluation of patients' coronary anatomy without exposing patients to the risks of invasive cardiac catheterization.
The purpose of this project is to compare CT angiography (CTA) to Tc-99m single photon emission computed tomography (Tc-99m SPECT)
We will enroll patients who are waiting for a CICA or who have been referred for a TC-99m SPECT or CTA scans at the University of Ottawa Heart Institute. Consenting patients who are waiting for a CICA will have both a CTA and a Tc-99m SPECT scan. Consenting patients referred for a CTA or Tc-99m SPECT will have both the CTA and Tc-99m SPECT in a random order but not CICA (unless ordered by your physician).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients referred for Tc-99m SPECT or CTA; or
- •Patients referred for CICA without preceding (< 12 months) MPI or CTA
排除标准
- •Previous revascularization (PCI or CABG)
- •Age < 18 years or lack of consent
- •Renal Insufficiency (GFR < 60 ml/min)
- •Allergy or contraindication to contrast agent or dipyridamole
- •Refractory angina requiring urgent/emergent coronary angiography
- •Contraindication to radiation exposure (e.g. pregnancy)
- •Uncontrolled HR
- •Atrial fibrillation, frequent atrial or ventricular ectopy (> 1/minute)
- •Unable to perform 10 second breath-hold
结局指标
主要结局
To measure the accuracy of CTA to SPECT for the diagnosis of CAD
时间窗: 1 year
次要结局
- To examine the accuracy of CTA predicting the mode of treatment: Medical therapy or revascularization (PCI versus CABG)(1 year)
研究者
Benjamin Chow
MD
Ottawa Heart Institute Research Corporation