Effects of H1-Antagonist on Stages of Human Information Processing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- P300 latency and LRP onset latency
研究概览
简要总结
The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.
详细描述
The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy as determined by a physician
排除标准
- •present or history of any neurological of psychiatric disease
- •present or history of any substance abuse
研究组 & 干预措施
healthy volunteers
干预措施: dexchlorpheniramine, lorazepam (Drug)
结局指标
主要结局
P300 latency and LRP onset latency
时间窗: 1.5 hours after treatment
次要结局
- Words recalled(1.5 hours after treatment)