Atteinte Tissulaire au Cours de l'ischémie Chronique d'Effort. Validation d'un modèle d'étude du Muscle Sartorius Humain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Activity differences in mitochondrial complex I between the distal and proximal levy in group 1 and group 2.
研究概览
简要总结
The purpose of this study is to evaluate the effect of muscle ischemia during claudication on mitochondrial function.
Comparison to patients with arterial disease but absence of lower limb claudication (Cardiac group) feasibility study.
详细描述
Assess the feasibility of the study of micro-vascular function and mitochondrial on muscle sample (sartorius) in a group of arterial disease and non arteriopathy group.
Analysis of the activity of mitochondrial chain Immunochemistry of tissue markers
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intervention for femoropopliteal bypass (PAD group)
- •Intervention for saphenous withdrawal for coronary bypass surgery (cardiac group)
排除标准
- •Participate in another biomedical research
- •Pregnant woman
结局指标
主要结局
Activity differences in mitochondrial complex I between the distal and proximal levy in group 1 and group 2.
时间窗: 1 week
Measurement of mitochondrial complex 1 activity (arbitrary units) on muscle biopsies by the laboratory of biochemistry. Comparison of the results observed on the same miuscle at the proximal level (assumed normal in both groups) and distal level (assumed ischemic in claudicants but not in cardiac patients without limb symptoms.
次要结局
未报告次要终点