Effect of Ingestion of Beet Juice on Endothelial Function, Arterial Stiffness and Muscle Oxygenation Parameters in People Living With HIV / AIDS Using Antiretroviral Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Skeletal Muscle Oxygenation
研究概览
简要总结
Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Double- Blind
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •HIV infection for a period of 1 year or greater
- •Regular use of high-potency antiretroviral therapy for at least one year
排除标准
- •Individuals who are physically active
- •Individuals who are allergic to some component of beet
- •Individuals who use nutritional and / or pharmacological ergogenics
- •Individuals receiving antibiotics or who have osteomioarticular problems
研究组 & 干预措施
Beetroot juice
Beetroot Juice cotaining on average 9mmol of nitrate per dose
干预措施: Beetroot Juice (Dietary Supplement)
Placebo beet juice (Nitrate depleted)
Beetroot juice nitrate depleted
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Skeletal Muscle Oxygenation
时间窗: Baseline and approximately after 150 minutes of beetroot juice consumption
Changes in skeletal muscle oxygenation in response to exercise will be evaluated by using a near-infrared spectroscopy device.
Brachial artery flow-mediated dilatation
时间窗: Baseline and approximately after 150 minutes of beetroot juice consumption
The brachial artery flow-mediated dilation will be evaluated by using an ultrasound device.
次要结局
- Urinary nitrate concentrations(Baseline and approximately 30, 90, and 150 minutes after beetroot juice consumption)
研究者
Thiago Alvares
PhD
Universidade Federal do Rio de Janeiro