Overall Perspective on the Characteristics of Genetic Mutation in Recurrent Cervical Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Frequency of genetic mutations
研究概览
简要总结
Little is known about the characteristics of genetic mutation in recurrent cervical cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy and immunotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years or older
- •Pathology confirmed of recurrent cervical adenocarcinoma, squamous carcinoma or adenosquamous carcinoma
- •With available materials for analysis
- •With detailed clinicopathological information
- •Given consent to participate the trial
排除标准
- •Not meeting all of the inclusion criteria
结局指标
主要结局
Frequency of genetic mutations
时间窗: Two years
Frequency of various genetic mutations among recruited patients
次要结局
- Frequency of microsatellite Instability(Two years)
- Total mutation burden(Two years)
- Expression rates of PD-1 and PD-L1 antibodies(Two years)
研究者
Lei Li
Professor
Peking Union Medical College Hospital