Non-invasive Functional Assessment of Coronary Stenoses Using CT Coronary Angiography and Computational Fluid Dynamics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 103
- 试验地点
- 1
- 主要终点
- fractional flow reserve
研究概览
简要总结
Angiographically obtained fractional flow reserve(FFR) could provide functional and clinical information about stenotic lesion, but the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. CT coronary angiography is non-invasive tool to evaluate lesion severity and lately developing computational fluid dynamics could provide functional information. The investigators build a patient specific model of computational fluid dynamics by CT coronary angiography and evaluate the functional significance by measuring fractional flow reserve via CT coronary angiography and computational fluid dynamics, and investigate its long-term prognostic implications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Investigator)
盲法说明
With masking value of FFR derived from coronary CT angiography to the investigators, FFR is measured and patients have been followed-up.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Significant stenosis at CT angiography
- •Normal ejection fraction on echocardiography
- •Informed consented patient
排除标准
- •total occlusion and collateral flow to target vessel
- •AV conduction abnormality
- •Left ventricular hypertrophy
- •significant valvular heart or primary myocardial disease
研究组 & 干预措施
CT and FFR
干预措施: CT coronary angiography and computational fluid dynamics (Device)
结局指标
主要结局
fractional flow reserve
时间窗: 1day
fractional flow reserve of stenotic coronary artery
target vessel failure
时间窗: 10 year
composite of cardiovascular death, target vessel myocardial infarction, target vessel revascularization
次要结局
未报告次要终点
研究者
Bon-Kwon Koo
Associate professor
Seoul National University Hospital