Effect of resveratrol on insulin sensitivity and metabolic profile in type 2 diabetics - Resveratrol and type 2 diabetes

niversiteit Maastricht0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•* Male sex
•* Age: 40-70 years
•* Body fat percentage >25, BMI 27-35 kg/m2
•* Diagnosed with type 2 diabetes at least one year before the start of the study
•* Well-controlled type 2 diabetics: HBA1C < 8.0%
•* Oral glucose lowering medication (metformin only or in combination with sulfonylurea agents)
•* Sedentary (Not more than 2 hours of sports a week, no active job that requires strenuous physical activity)
•* Stable dietary habits
•* Willingness to abstain from resveratrol-containing food products

•* Unstable body weight (weight gain or loss > 3kg in the last three months)
•* Total body fat percentage < 25%
•* Hemoglobin <7.8 mmol/l
•* Engagement in programmed exercise > 2 hours total per week
•* Impaired kidney and/or hepatic function
•Creatinine 50-100 umol/L;Liver enzymes, within 2 times of normal range of laboratory standard
•(ASAT <60 U/L, ALAT <70 U/L, Billi <40 umol/L, gamma-GT <80 U/L)
•* No diabetes related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, retinopathy.
•* Insulin dependent Diabetic subjects.
•* Anti-coagulants
•* Insulin therapy
•* Intake of dietary supplements except vitamins and minerals
•* Unwillingness to restrict high-resveratrol-containing food products
•* Current alcohol consumption > 20 grams/day
•* Participation in another biomedical study within 1 month before the first screening visit
•* Any contraindication to MRI scanning. These contra-indictations include patients with following devices:
•o Central nervous system aneurysm clip
•o Implanted neural stimulator
•o Implanted cardiac pacemaker of defibrillator
•o Cochlear implant
•o Insulin pump
•o Or metal containing corpora aliena in the eye or brains
•* Subjects who don*t want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study.

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