Inflammatory Mediators Associated With Infection by Respiratory Syncytial Virus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Levels of inflammatory mediators in sputum
研究概览
简要总结
Infection with human respiratory syncytial (RS) virus is the most common cause of hospital stay due to pediatric lower respiratory tract infection. An exaggerated immune response contributes to the pathogenesis and small children may have over reactive airways for a long time after an infection.
New research has shown that polymorphonuclear leukocytes (PMNs) are stimulated by the virus. Besides fighting the infection they also cause collateral damage to the host. Among other mechanisms PMNs stimulates mucus formation that affects breathing. They also secrete enzymes, toxic proteins and free radicals that may cause harm to lung tissue and airways.
The current project strives towards identifying and quantifying inflammatory mediators in sputum, urine and blood of children with severe RS-virus infection. The ultimate aim of the project is to, in detail, describe proteins contributing to the pathogenesis of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admission to pediatric intensive care unit
- •Clinical need for invasive ventilation
- •Clinical need for intravascular catheterization
- •Clinical need for urine bladder catheterization
- •Patients with verified or suspected RS-virus-infection or no respiratory tract infection (control group)
排除标准
- •Chronic inflammatory lung disease
结局指标
主要结局
Levels of inflammatory mediators in sputum
时间窗: Up to three weeks
Simultaneous detection and quantification of hundreds of potential mediators using mass-spectrometry
Levels of inflammatory mediators in blood
时间窗: Up to three weeks
Simultaneous detection and quantification of hundreds of potential mediators using mass-spectrometry
Levels of inflammatory mediators in urine
时间窗: Up to three weeks
Simultaneous detection and quantification of hundreds of potential mediators using mass-spectrometry
次要结局
- Lung function as measured by spirometry(Within 10 years)
- Disease severity as measured by sequential organ failure assessment score (SOFA-score)(Up to 30-days)
- Lung function as measured in respirator(Up to 30-days)
研究者
Robert Frithiof
Principal Investigator
Uppsala University