NCT06714149招募中不适用
Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium
prof. dr. Rik Schrijvers2 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2022年6月29日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Specific IgE reactivity (in-house developed) against environmental and experimental pollen samples
研究概览
简要总结
The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.
详细描述
The investigators want to study allergen-specific IgE reactivity from a cross-sectional sample of pollen-allergic patients (and negative controls) against environmental and experimental pollen samples. Following aspects will be compared:
- To study the basophil degranulation with different amounts of pollen on fresh patient-derived basophils, to determine the concentration of pollen needed to degranulate 5% (EC5), and 50% (EC50) of basophils.
- To study he overall intensity (quantitative), as well as IgE-mediated hyper- or hyporecognition of different fragments in the pollen samples (qualitative) in a subset of patients.
- To associate allergic rhinoconjunctivitis and food-pollen syndrome related symptoms with reactivity to different pollen samples.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Positive skin prick test for grass and/or birch pollen
排除标准
- •Desensitization therapy during the last two years
结局指标
主要结局
Specific IgE reactivity (in-house developed) against environmental and experimental pollen samples
时间窗: From time of inclusion to 12 months
The investigators want to measure and compare sIgE values (kUA/L) towards different pollen samples.
次要结局
- Basophil degranulation with different amounts of pollen on fresh patient-derived basophils.(From time of inclusion to 12 months)
- Overall intensity (quantitative) of IgE reactivity to pollen samples in a subset of patients.(From time of inclusion to 12 months)
- IgE-mediated hyper- or hyporecognition of different fragments in the pollen samples (qualitative) in a subset of patients.(From time of inclusion to 12 months)
研究者
prof. dr. Rik Schrijvers
Prof. dr.
Universitaire Ziekenhuizen KU Leuven
研究点 (2)
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