NCT02732509已完成不适用
Chronic Inflammation and Exercise Responsiveness
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 146
- 试验地点
- 1
- 主要终点
- Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles
研究概览
简要总结
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 30-55 years
- •BMI 19-45 kg/m2
排除标准
- •Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
- •Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
- •Renal insufficiency/failure (serum creatinine > 1.5mg/dl)
- •Oral warfarin group medications or history of blood clotting disorders.
- •Pregnancy or breastfeeding
- •Alcohol consumption greater than 2 glasses/day or other substance abuse
- •Untreated or uncontrolled thyroid disorders
- •Debilitating chronic disease (at the discretion of the investigators)
结局指标
主要结局
Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles
时间窗: 1 day
次要结局
未报告次要终点
研究者
Ian R. Lanza
Associate Professor of Medicine
Mayo Clinic
研究点 (1)
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