Determination of Half-life of the Carboxyhemoglobin Level and Utility of High Flow Nasal Cannula in Carbon Monoxide Toxicity in the Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Half life of COHb
研究概览
简要总结
determination of the half-life of COHb in CO-poisoned patients with high flow nasal oxygen therapy in the ED.
详细描述
Carbon monoxide (CO) poisoning is common and potentially fatal environmental emergency which requires immediate attention. It is responsible for up to 40,000 emergency department (ED) visits and 5000 to 6000 deaths per year, making it one of the leading causes of poisoning death in the United States. The management options for CO poisoning are limited to high flow oxygen by face mask or hyperbaric oxygen treatment. While half-life of carboxyhemoglobin (COHb) in a patient treating with high flow oxygen via a nonbreathing face mask is 90 minutes, it becomes 30 minutes with hyperbaric oxygen treatment (HBO).
The hypothesis of this study is using high flow nasal oxygen therapy in the CO poisoning may be more effective and safer treatment method comparing to standard oxygen therapy in the ED. Also, it may be a safe promising alternative of hyperbaric oxygen therapy.
The aim of the study is to determine the half-life of COHb in CO-poisoned patients with high flow nasal oxygen therapy in the ED.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients who are admitted to the emergency department with CO poisoning with a CoHB level of >10%.
- •The patients who accept to participate in the study.
排除标准
- •The patients who are <18 years old.
- •The patients who need mechanical ventilation
- •The patients who are implemented oxygen more than 30 minutes before the ED admission
- •The patients who will be transferred to the hyperbaric oxygen center before the CoHB levels are decreased to the half.
研究组 & 干预措施
HFNC therapy
Fisher&Paykel AIRVO™ 2 High Flow Nasal Cannula Therapy will be implemented to CO-poisoned patients. Oxygen flow rate will be started 60 L/min and be decreased as the patient has requested.
干预措施: Fisher&Paykel AIRVO™ 2 High Flow Nasal Cannula Therapy (Device)
结局指标
主要结局
Half life of COHb
时间窗: between 20 and 120 minutes
Half life of COHb levels (%) under the high flow nasal oxygen therapy. Elimination rate of COHb will be determined in every 10 minutes according to venous blood gas COHb level.
次要结局
- Flow Rate Tolerability(Between 0 and 120 minutes)
- Flow Temperature Tolerability(Between 0 and 120 minutes.)
- Adverse Events(between 0 and 120 minutes)
- Device Comfort(Between 0 and 120 minutes)
研究者
Ibrahim Ulas Ozturan
Principle Investigator, MD
Kocaeli University